Healthy Brain Network Serial Scanning Initiative (HBN-SSI)


The primary goal of the Child Mind Institute Healthy Brain Network-Serial Scanning Initiative (HBN-SSI) was to assess and compare test-retest reliabilities for full-brain connectivity patterns derived from functional MRI data obtained during different scan conditions. The data resource was generated in preparation for the launch of the Child Mind Institute Healthy Brain Network (HBN) - a large-scale data collection effort focused on the generation of an open resource for the study child and adolescent mental health. Following the model of the MyConnectome Project, individuals were scanned serially to allow for assessments of reliability over time, as well as to enable highly detailed characterizations of brain organization at the individual-level.

For the HBN-SSI, 13 adult participants (ages: 21-42) were repeatedly scanned under each of four scan conditions across 12 sessions. The specific conditions were intended to differ with respect to level of engagement, and included: 1) rest, 2) naturalistic viewing of a sequence of abstract shapes (i.e., "Inscapes", Vanderwal, 2015), 3) naturalistic viewing of highly engaging movies (Betti, 2013), and 4) performance of an active task (i.e., an Erickson flanker task, with no-Go trials included). For each of the non-rest conditions, three different stimuli were used repeated four times across the 12 sessions to allow for consideration of repetition effects.

Given the focus on naturalistic viewing, an additional scan session containing a full viewing of “Raiders of the Lost Ark” was included; this data can be used to facilitate explorations of hyper-alignment approaches (see the works of Haxby J. and colleagues). Additionally, although not a primary focus of the data collection, structural imaging data was collected, which are being shared as well: 1) MPRAGE, 2) diffusion kurtosis imaging, 3) quantitative T1/T2 anatomical imaging, 4) magnetization transfer.

What is the Healthy Brain Network?

The Child Mind Institute Healthy Brain Network (CMI-HBN) is an open science data generation initiative that aims to provide the scientific community with a large-scale multimodal imaging dataset focused on child and adolescent mental health and learning disorders (n = 10,000; ages 5-21). In addition to connectomics-focused functional and structural MR imaging scanning, research participation includes extensive mental health, learning and behavioral assessments carried out by a licensed team of clinicians. To maximize the value of participation for individuals, participants and their families are provided a comprehensive evaluation report, which includes testing results, a diagnostic assessment, and treatment recommendations.

The HBN-SSI Team

Michael Milham, MD, PhD, Cameron Craddock, PhD, Jasmine Escalera, PhD
Cameron Craddock
Logisitics and Data Collection
Natan Vega Potler, Meagan Kovacs, Natalie Grant-Villegas, Yael Osman, Jasmine Escalera
Programming, Technical and Analytic Support
David O’Connor, Ting Xu, John Pellman, Lei Ai, Daniel Clark, Cameron Craddock
Neuroinformatics (AWS)
John Pellman, David O'Connor, Cameron Craddock
Miscellaneous Support and Guidance
Tamara Vanderwal, Satrajit Ghosh, Lucas Parra, Samantha Cohen


The Healthy Brain Network and its supporting initiatives are supported by philanthropic contributions from the following individuals, foundations and organizations: Lee Alexander, Lee Alexander, Robert Allard, Lisa Bilotti Foundation, Inc., Margaret Billoti, Christopher Boles, Brooklyn Nets, Agapi and Bruce Burkhard, Randolph Cowen and Phyllis Green, Elizabeth and David DePaolo, Charlotte Ford, Valesca Guerrand-Hermes, Sarah and Geoffrey Gund, George Hall, Joseph Healey and Elaine Thomas, Hearst Foundations, Anton and Robin Katz, Rachael and Marshall Levine, Ke Li, Jessica Lupovici, Javier Macaya, Christine and Richard Mack, Susan Miller and Byron Grote, John and Amy Phelan, Linnea and George Roberts, Jim and Linda , Robinson Foundation, Inc, Caren and Barry Roseman, Zibby Schwarzman, David Shapiro and Abby Pogrebin, Stavros Niarchos Foundation, Nicholas Van Dusen, David Wolkoff and Stephanie Winston Wolkoff and the Donors to the Brant Art Auction of 2012.


We would like to thank Tamara Vanderwal, Satrajit Ghosh, Lucas Parra, and Samantha Cohen for their input in conceptualizing and designing the experimetal paradigms used.

Special thanks to Russ Poldrack for sharing insights from the MyConnectome Project experience during the conceptualization of the HBN-SSI.

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